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Dose-dependent constipation with higher doses of quetiapine: a case series.

Raedler TJ, Reimer J, Wiedemann K

Department of Psychiatry, University Medical Center Hamburg-Eppendorf, Hamburg, Germany. traedler@uke.uni-hamburg.de

Quetiapine is a dopamine D2 and serotonin 5-HT2 antagonist with antipsychotic and mood-stabilizing properties. Recent studies suggest that higher doses of quetiapine combine superior therapeutic efficacy with good tolerability. We present five patients, in whom treatment with higher doses of quetiapine was associated with constipation. Our observations raise the question of dose-dependent constipation under treatment with quetiapine.

Published 23 May 2007 in Int Clin Psychopharmacol, 22(4): 244-6.
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